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Review article: Medical guidelines

Vol. 155 No. 3 (2025)

Swiss Stroke Society position paper on atrial fibrillation monitoring and management after ischaemic stroke: a shift from understanding the index stroke to preventing the next one

Cite this as:
Swiss Med Wkly. 2025;155:4170
Published
06.03.2025

Summary

This position paper on the detection of atrial fibrillation after ischaemic stroke is a statement of the “Heart and Brain” committee of the Swiss Stroke Society. This position paper summarises present knowledge on the detection of atrial fibrillation after ischaemic stroke or transient ischaemic attack. An interdisciplinary standard for monitoring on the stroke unit and after discharge is proposed respecting recent developments and Swiss particularities. The main evolution in the field is that the role of atrial fibrillation screening after stroke or transient ischaemic attack has shifted from understanding the index stroke to preventing the next stroke; it therefore should also be performed in patients with certain other stroke aetiologies, e.g. symptomatic carotid artery stenosis. The duration of atrial fibrillation monitoring should be based on an individualised risk assessment incorporating clinical characteristics as well as cardiac and laboratory biomarkers. Given the paucity of randomised controlled data on this topic, this position paper intends to give practical advice to healthcare professionals involved in stroke care in Switzerland based on a consensus between experts in the field.

References

  1. Feigin VL, Stark BA, Johnson CO, Roth GA, Bisignano C, Abady GG, et al.; GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021 Oct;20(10):795–820. doi: https://doi.org/10.1016/S1474-4422(21)00252-0
  2. Al-Khayatt BM, Salciccioli JD, Marshall DC, Krahn AD, Shalhoub J, Sikkel MB. Paradoxical impact of socioeconomic factors on outcome of atrial fibrillation in Europe: trends in incidence and mortality from atrial fibrillation. Eur Heart J. 2021 Feb;42(8):847–57. doi: https://doi.org/10.1093/eurheartj/ehaa1077
  3. Yaghi S, Kamel H. Stratifying stroke risk in atrial fibrillation beyond clinical risk scores. Stroke. 2017 Oct;48(10):2665–70. doi: https://doi.org/10.1161/STROKEAHA.117.017084
  4. Yiin GS, Li L, Bejot Y, Rothwell PM. Time Trends in Atrial Fibrillation-Associated Stroke and Premorbid Anticoagulation: Population-Based Study and Systematic Review. Stroke. 2019 Jan;50(1):21–7. doi: https://doi.org/10.1161/STROKEAHA.118.022249
  5. Volgman AS, Benjamin EJ, Curtis AB, Fang MC, Lindley KJ, Naccarelli GV, et al.; American College of Cardiology Committee on Cardiovascular Disease in Women. Women and atrial fibrillation. J Cardiovasc Electrophysiol. 2021 Oct;32(10):2793–807. doi: https://doi.org/10.1111/jce.14838
  6. Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al.; ESC Scientific Document Group. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021 Feb;42(5):373–498. doi: https://doi.org/10.1093/eurheartj/ehaa612
  7. Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001 May;285(18):2370–5. doi: https://doi.org/10.1001/jama.285.18.2370
  8. Linde C, Bongiorni MG, Birgersdotter-Green U, Curtis AB, Deisenhofer I, Furokawa T, et al. Sex differences in cardiac arrhythmia: A consensus document of the european heart rhythm association, endorsed by the heart rhythm society and Asia pacific heart rhythm society. Europace. 2018;20(10):1565-1565ao. doi: https://doi.org/10.1093/europace/euy067
  9. Lin HJ, Wolf PA, Kelly-Hayes M, Beiser AS, Kase CS, Benjamin EJ, et al. Stroke severity in atrial fibrillation. The Framingham Study. Stroke. 1996 Oct;27(10):1760–4. doi: https://doi.org/10.1161/01.STR.27.10.1760
  10. Hart RG, Eikelboom JW. Reducing the risk of recurrent stroke in patients with AF. Lancet Neurol. 2012 Jun;11(6):479–81. doi: https://doi.org/10.1016/S1474-4422(12)70096-0
  11. Seiffge DJ, Werring DJ, Paciaroni M, Dawson J, Warach S, Milling TJ, et al. Timing of anticoagulation after recent ischaemic stroke in patients with atrial fibrillation. Lancet Neurol. 2019 Jan;18(1):117–26. doi: https://doi.org/10.1016/S1474-4422(18)30356-9
  12. Seiffge DJ, De Marchis GM, Koga M, Paciaroni M, Wilson D, Cappellari M, et al.; RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen, and Verona registry collaborators. Ischemic Stroke despite Oral Anticoagulant Therapy in Patients with Atrial Fibrillation. Ann Neurol. 2020 Feb;87(5):677–87. doi: https://doi.org/10.1002/ana.25700
  13. Steger C, Pratter A, Martinek-Bregel M, Avanzini M, Valentin A, Slany J, et al. Stroke patients with atrial fibrillation have a worse prognosis than patients without: data from the Austrian Stroke registry. Eur Heart J. 2004 Oct;25(19):1734–40. doi: https://doi.org/10.1016/j.ehj.2004.06.030
  14. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007 Jun;146(12):857–67. doi: https://doi.org/10.7326/0003-4819-146-12-200706190-00007
  15. Sanna T, Diener HC, Passman RS, Di Lazzaro V, Bernstein RA, Morillo CA, et al.; CRYSTAL AF Investigators. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. 2014 Jun;370(26):2478–86. doi: https://doi.org/10.1056/NEJMoa1313600
  16. Bernstein RA, Kamel H, Granger CB, Piccini JP, Sethi PP, Katz JM, et al.; STROKE-AF Investigators. Effect of long-term continuous cardiac monitoring vs usual care on detection of atrial fibrillation in patients with stroke attributed to large- or small-vessel disease: the stroke-af randomized clinical trial. JAMA -. JAMA. 2021 Jun;325(21):2169–77. doi: https://doi.org/10.1001/jama.2021.6470
  17. Meinel TR, Branca M, De Marchis GM, Nedeltchev K, Kahles T, Bonati L, et al.; Investigators of the Swiss Stroke Registry. Prior Anticoagulation in Patients with Ischemic Stroke and Atrial Fibrillation. Ann Neurol. 2021 Jan;89(1):42–53. doi: https://doi.org/10.1002/ana.25917
  18. Xian Y, O’Brien EC, Liang L, Xu H, Schwamm LH, Fonarow GC, et al. Association of preceding antithrombotic treatment with acute ischemic stroke severity and in-hospital outcomes among patients with atrial fibrillation. JAMA -. JAMA. 2017 Mar;317(10):1057–67. doi: https://doi.org/10.1001/jama.2017.1371
  19. Schnabel RB, Haeusler KG, Healey JS, Freedman B, Boriani G, Brachmann J, et al. Searching for Atrial Fibrillation Poststroke: A White Paper of the AF-SCREEN International Collaboration. Circulation. 2019 Nov;140(22):1834–50. doi: https://doi.org/10.1161/CIRCULATIONAHA.119.040267
  20. Samim D, Choffat D, Vollenweider P, Waeber G, Marques-Vidal P, Méan M. Prevalence of atrial fibrillation : the Swiss population-based CoLaus|PsyCoLaus study. Herz. 2023 Feb;48(1):48–54. doi: https://doi.org/10.1007/s00059-021-05090-7
  21. Di Carlo A, Bellino L, Consoli D, Mori F, Zaninelli A, Baldereschi M, et al.; National Research Program: Progetto FAI. La Fibrillazione Atriale in Italia. Prevalence of atrial fibrillation in the Italian elderly population and projections from 2020 to 2060 for Italy and the European Union: the FAI Project. Europace. 2019 Oct;21(10):1468–75. doi: https://doi.org/10.1093/europace/euz141
  22. Meyer K, Simmet A, Arnold M, Mattle H, Nedeltchev K. Stroke events, and case fatalities in Switzerland based on hospital statistics and cause of death statistics. Swiss Med Wkly. 2009 Feb;139(5-6):65–9.
  23. Thompson LE, Maddox TM, Lei L, Grunwald GK, Bradley SM, Peterson PN, et al. Sex differences in the use of oral anticoagulants for atrial fibrillation: A report from the National Cardiovascular Data Registry (NCDR®) PINNACLE registry. J Am Heart Assoc. 2017 Jul;6(7):e005801. doi: https://doi.org/10.1161/JAHA.117.005801
  24. Lyrer F, Zietz A, Seiffge DJ, Koga M, Volbers B, Wilson D, et al.; NOACISP-LONGTERM, Erlangen Registry, CROMIS-2, SAMURAI-NVAF and Verona Registry collaborators. Atrial Fibrillation Detected before or after Stroke: role of Anticoagulation. Ann Neurol. 2023 Jul;94(1):43–54. doi: https://doi.org/10.1002/ana.26654
  25. Hariharan NN, Patel K, Sikder O, Perera KS, Diener HC, Hart RG, et al. Oral anticoagulation versus antiplatelet therapy for secondary stroke prevention in patients with embolic stroke of undetermined source: A systematic review and meta-analysis. Eur Stroke J. 2022 Jun;7(2):92–8. doi: https://doi.org/10.1177/23969873221076971
  26. Diener HC, Sacco RL, Easton JD, Granger CB, Bar M, Bernstein RA, et al. Antithrombotic Treatment of Embolic Stroke of Undetermined Source: RE-SPECT ESUS Elderly and Renally Impaired Subgroups. Stroke. 2020 Jun;51(6):1758–65. doi: https://doi.org/10.1161/STROKEAHA.119.028643
  27. Birnbaum LA, Kamel H, Sheth KN, Sharma R. Left Ventricular Dysfunction Among Patients With Embolic Stroke of Undetermined Source and the Effect of Rivaroxaban vs Aspirin A Subgroup Analysis of the NAVIGATE ESUS Randomized Clinical Trial. 2021;10065:1–7.
  28. Healey JS, Gladstone DJ, Swaminathan B, Eckstein J, Mundl H, Epstein AE, et al. Recurrent Stroke With Rivaroxaban Compared With Aspirin According to Predictors of Atrial Fibrillation: Secondary Analysis of the NAVIGATE ESUS Randomized Clinical Trial. JAMA Neurol. 2019 Jul;76(7):764–73. doi: https://doi.org/10.1001/jamaneurol.2019.0617
  29. ESOC 2023 Abstract Book. Eur Stroke J. 2023;8(2 suppl):3–669.
  30. World Stroke Congress. WSC23 Late Breaking Abstracts. Int J Stroke. 2023;18(3 suppl):421–58.
  31. Haeusler KG, Kirchhof P, Kunze C, Tütüncü S, Fiessler C, Malsch C, et al.; MonDAFIS Investigators. Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study. Lancet Neurol. 2021 Jun;20(6):426–36. doi: https://doi.org/10.1016/S1474-4422(21)00067-3
  32. Olma MC, Tütüncü S, Fiessler C, Kunze C, Krämer M, Steindorf-Sabath L, et al.; MonDAFIS Investigators [Link]. In-Hospital ECG Findings, Changes in Medical Management, and Cardiovascular Outcomes in Patients With Acute Stroke or Transient Ischemic Attack. J Am Heart Assoc. 2023 Jan;12(2):e027149. doi: https://doi.org/10.1161/JAHA.122.027149
  33. Kallmünzer B, Breuer L, Hering C, Raaz-Schrauder D, Kollmar R, Huttner HB, et al. A structured reading algorithm improves telemetric detection of atrial fibrillation after acute ischemic stroke. Stroke. 2012 Apr;43(4):994–9. doi: https://doi.org/10.1161/STROKEAHA.111.642199
  34. Rizos T, Güntner J, Jenetzky E, Marquardt L, Reichardt C, Becker R, et al. Continuous stroke unit electrocardiographic monitoring versus 24-hour Holter electrocardiography for detection of paroxysmal atrial fibrillation after stroke. Stroke. 2012 Oct;43(10):2689–94. doi: https://doi.org/10.1161/STROKEAHA.112.654954
  35. Uphaus T, Grings A, Gröschel S, Müller A, Weber-Krüger M, Wachter R, et al. Automatic detection of paroxysmal atrial fibrillation in patients with ischaemic stroke: better than routine diagnostic workup? Eur J Neurol. 2017 Jul;24(7):990–4. doi: https://doi.org/10.1111/ene.13326
  36. Chen LY, Chung MK, Allen LA, Ezekowitz M, Furie KL, McCabe P, et al.; American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Quality of Care and Outcomes Research; and Stroke Council. Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association. Circulation. 2018 May;137(20):e623–44. doi: https://doi.org/10.1161/CIR.0000000000000568
  37. Haeusler KG, Tütüncü S, Schnabel RB. Detection of Atrial Fibrillation in Cryptogenic Stroke. Curr Neurol Neurosci Rep. 2018 Aug;18(10):66. doi: https://doi.org/10.1007/s11910-018-0871-1
  38. Wachter R, Gröschel K, Gelbrich G, Hamann GF, Kermer P, Liman J, et al.; Find-AF(randomised) Investigators and Coordinators. Holter-electrocardiogram-monitoring in patients with acute ischaemic stroke (Find-AFRANDOMISED): an open-label randomised controlled trial. Lancet Neurol. 2017 Apr;16(4):282–90. doi: https://doi.org/10.1016/S1474-4422(17)30002-9
  39. Sposato LA, Cipriano LE, Saposnik G, Ruíz Vargas E, Riccio PM, Hachinski V. Diagnosis of atrial fibrillation after stroke and transient ischaemic attack: a systematic review and meta-analysis. Lancet Neurol. 2015 Apr;14(4):377–87. doi: https://doi.org/10.1016/S1474-4422(15)70027-X
  40. Alvarado-Bolaños A, Ayan D, Khaw AV, Mai LM, Mandzia JL, Bogiatzi C, et al. Differences in Stroke Recurrence Risk Between Atrial Fibrillation Detected on ECG and 14-Day Cardiac Monitoring. Stroke. 2023 Aug;54(8):2022–30. doi: https://doi.org/10.1161/STROKEAHA.123.043672
  41. Van Gelder IC, Healey JS, Crijns HJ, Wang J, Hohnloser SH, Gold MR, et al. Duration of device-detected subclinical atrial fibrillation and occurrence of stroke in ASSERT. Eur Heart J. 2017 May;38(17):1339–44. doi: https://doi.org/10.1093/eurheartj/ehx042
  42. Svendsen JH, Diederichsen SZ, Højberg S, Krieger DW, Graff C, Kronborg C, et al. Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial. Lancet. 2021 Oct;398(10310):1507–16. doi: https://doi.org/10.1016/S0140-6736(21)01698-6
  43. Svennberg E, Friberg L, Frykman V, Al-Khalili F, Engdahl J, Rosenqvist M. Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial. Lancet. 2021 Oct;398(10310):1498–506. doi: https://doi.org/10.1016/S0140-6736(21)01637-8
  44. Kirchhof P, Toennis T, Goette A, Camm AJ, Diener HC, Becher N, et al.; NOAH-AFNET 6 Investigators; NOAH-AFNET6 sites and investigators. Anticoagulation with Edoxaban in Patients with Atrial High-Rate Episodes. N Engl J Med. 2023 Sep;389(13):1167–79. doi: https://doi.org/10.1056/NEJMoa2303062
  45. Becher N, Toennis T, Bertaglia E, Blomström-Lundqvist C, Brandes A, Cabanelas N, et al. Anticoagulation with edoxaban in patients with long atrial high-rate episodes ≥24 h. Eur Heart J. 2024 Mar;45(10):837–49. doi: https://doi.org/10.1093/eurheartj/ehad771
  46. Healey JS, Lopes RD, Granger CB, Alings M, Rivard L, McIntyre WF, et al.; ARTESIA Investigators. Apixaban for Stroke Prevention in Subclinical Atrial Fibrillation. N Engl J Med. 2024 Jan;390(2):107–17. doi: https://doi.org/10.1056/NEJMoa2310234
  47. McIntyre WF, Benz AP, Becher N, Healey JS, Granger CB, Rivard L, et al. Direct Oral Anticoagulants for Stroke Prevention in Patients With Device-Detected Atrial Fibrillation: A Study-Level Meta-Analysis of the NOAH-AFNET 6 and ARTESiA Trials. Circulation. 2024 Mar;149(13):981–8. doi: https://doi.org/10.1161/CIRCULATIONAHA.123.067512
  48. Kaplan RM, Koehler J, Ziegler PD, Sarkar S, Zweibel S, Passman RS. Stroke risk as a function of atrial fibrillation duration and CHA2DS2-VASc score. Circulation. 2019 Nov;140(20):1639–46. doi: https://doi.org/10.1161/CIRCULATIONAHA.119.041303
  49. Hilkens NA, Li L, Rothwell PM, Algra A, Greving JP. Refining prediction of major bleeding on antiplatelet treatment after transient ischaemic attack or ischaemic stroke. Eur Stroke J. 2020 Jun;5(2):130–7. doi: https://doi.org/10.1177/2396987319898064
  50. Best JG, Ambler G, Wilson D, Lee KJ, Lim JS, Shiozawa M, et al.; Microbleeds International Collaborative Network. Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Lancet Neurol. 2021 Apr;20(4):294–303. doi: https://doi.org/10.1016/S1474-4422(21)00024-7
  51. Rossini R, Peirone A. When to set anticoagulant therapy in asymptomatic AF? looking for a cut-off duration. Eur Hear Journal, Suppl. 2022;24(Si):I143–7.
  52. Cameron A, Cheng HK, Lee RP, Doherty D, Hall M, Khashayar P, et al. Biomarkers for Atrial Fibrillation Detection After Stroke: Systematic Review and Meta-analysis. Neurology. 2021 Nov;97(18):e1775–89. doi: https://doi.org/10.1212/WNL.0000000000012769
  53. Binici Z, Intzilakis T, Nielsen OW, Køber L, Sajadieh A. Excessive supraventricular ectopic activity and increased risk of atrial fibrillation and stroke. Circulation. 2010 May;121(17):1904–11. 10.1161/CIRCULATIONAHA.109.874982
  54. Thijs VN, Brachmann J, Morillo CA, Passman RS, Sanna T, Bernstein RA, et al. Predictors for atrial fibrillation detection after cryptogenic stroke: results from CRYSTAL AF. Neurology. 2016 Jan;86(3):261–9. doi: https://doi.org/10.1212/WNL.0000000000002282
  55. Gladstone DJ, Dorian P, Spring M, Panzov V, Mamdani M, Healey JS, et al.; EMBRACE Steering Committee and Investigators. Atrial premature beats predict atrial fibrillation in cryptogenic stroke: results from the EMBRACE trial. Stroke. 2015 Apr;46(4):936–41. doi: https://doi.org/10.1161/STROKEAHA.115.008714
  56. Wolder LD, Graff C, Baadsgaard KH, Langgaard ML, Polcwiartek C, Ji-Young Lee C, et al. Electrocardiographic P terminal force in lead V1, its components, and the association with stroke and atrial fibrillation or flutter. Heart Rhythm. 2023 Mar;20(3):354–62. doi: https://doi.org/10.1016/j.hrthm.2022.11.010
  57. Saric M, Armour AC, Arnaout MS, Chaudhry FA, Grimm RA, Kronzon I, et al. Guidelines for the Use of Echocardiography in the Evaluation of a Cardiac Source of Embolism. J Am Soc Echocardiogr. 2016 Jan;29(1):1–42. doi: https://doi.org/10.1016/j.echo.2015.09.011
  58. Perlepe K, Sirimarco G, Strambo D, Eskandari A, Karagkiozi E, Vemmou A, et al. Left atrial diameter thresholds and new incident atrial fibrillation in embolic stroke of undetermined source. Eur J Intern Med. 2020 May;75:30–4. 10.1016/j.ejim.2020.01.002
  59. Schwamm LH, Kamel H, Granger CB, Piccini JP, Katz JM, Sethi PP, et al.; STROKE AF Investigators. Predictors of Atrial Fibrillation in Patients With Stroke Attributed to Large- or Small-Vessel Disease: A Prespecified Secondary Analysis of the STROKE AF Randomized Clinical Trial. JAMA Neurol. 2023 Jan;80(1):99–103. doi: https://doi.org/10.1001/jamaneurol.2022.4038
  60. Baturova MA, Sheldon SH, Carlson J, Brady PA, Lin G, Rabinstein AA, et al. Electrocardiographic and Echocardiographic predictors of paroxysmal atrial fibrillation detected after ischemic stroke. BMC Cardiovasc Disord. 2016 Nov;16(1):209. doi: https://doi.org/10.1186/s12872-016-0384-2
  61. Waldenhjort D, Sobocinski Doliwa P, Alam M, Frykman-Kull V, Engdahl J, Rosenqvist M, et al. Echocardiographic measures of atrial function may predict atrial fibrillation in stroke patients. Scand Cardiovasc J. 2016 Aug;50(4):236–42. doi: https://doi.org/10.1080/14017431.2016.1175657
  62. Stahrenberg R, Edelmann F, Haase B, Lahno R, Seegers J, Weber-Krüger M, et al. Transthoracic echocardiography to rule out paroxysmal atrial fibrillation as a cause of stroke or transient ischemic attack. Stroke. 2011 Dec;42(12):3643–5. doi: https://doi.org/10.1161/STROKEAHA.111.632836
  63. Favilla CG, Ingala E, Jara J, Fessler E, Cucchiara B, Messé SR, et al. Predictors of finding occult atrial fibrillation after cryptogenic stroke. Stroke. 2015 May;46(5):1210–5. doi: https://doi.org/10.1161/STROKEAHA.114.007763
  64. Bernstein RA, Di Lazzaro V, Rymer MM, Passman RS, Brachmann J, Morillo CA, et al. Infarct Topography and Detection of Atrial Fibrillation in Cryptogenic Stroke: results from CRYSTAL AF. Cerebrovasc Dis. 2015;40(1-2):91–6. doi: https://doi.org/10.1159/000437018
  65. Pimentel BC, Ingwersen T, Haeusler KG, Schlemm E, Forkert ND, Rajashekar D, et al. Association of stroke lesion shape with newly detected atrial fibrillation - Results from the MonDAFIS study. Eur Stroke J. 2022 Sep;7(3):230–7. doi: https://doi.org/10.1177/23969873221100895
  66. Vynckier J, Kaesmacher J, Wardlaw JM, Roten L, Beyeler M, Belachew NF, et al. Phenotypes of Chronic Covert Brain Infarction in Patients With First-Ever Ischemic Stroke: A Cohort Study. Stroke. 2022 Feb;53(2):558–68. doi: https://doi.org/10.1161/STROKEAHA.121.034347
  67. Demeestere J, Fieuws S, Lansberg MG, Lemmens R. Detection of Atrial Fibrillation Among Patients With Stroke Due to Large or Small Vessel Disease: A Meta-Analysis. J Am Heart Assoc. 2016 Sep;5(9):e004151. doi: https://doi.org/10.1161/JAHA.116.004151
  68. Schweizer J, Arnold M, König IR, Bicvic A, Westphal LP, Schütz V, et al. Measurement of Midregional Pro-Atrial Natriuretic Peptide to Discover Atrial Fibrillation in Patients With Ischemic Stroke. J Am Coll Cardiol. 2022 Apr;79(14):1369–81. doi: https://doi.org/10.1016/j.jacc.2022.01.042
  69. Wachter R, Lahno R, Haase B, Weber-Krüger M, Seegers J, Edelmann F, et al. Natriuretic peptides for the detection of paroxysmal atrial fibrillation in patients with cerebral ischemia—the Find-AF study. PLoS One. 2012;7(4):e34351. doi: https://doi.org/10.1371/journal.pone.0034351
  70. Fonseca AC, Brito D, Pinho e Melo T, Geraldes R, Canhão P, Caplan LR, et al. N-terminal pro-brain natriuretic peptide shows diagnostic accuracy for detecting atrial fibrillation in cryptogenic stroke patients. Int J Stroke. 2014 Jun;9(4):419–25. doi: https://doi.org/10.1111/ijs.12126
  71. Arnold M, Nakas C, Luft A, Christ-Crain M, Leichtle A, Katan M. Independent Prognostic Value of MRproANP (Midregional Proatrial Natriuretic Peptide) Levels in Patients With Stroke Is Unaltered Over Time. Stroke. 2020 Jun;51(6):1873–5. doi: https://doi.org/10.1161/STROKEAHA.120.029333
  72. De Marchis GM, Schneider J, Weck A, Fluri F, Fladt J, Foerch C, et al. Midregional proatrial natriuretic peptide improves risk stratification after ischemic stroke. Neurology. 2018 Feb;90(6):e455–65. doi: https://doi.org/10.1212/WNL.0000000000004922
  73. Katan M, Fluri F, Schuetz P, Morgenthaler NG, Zweifel C, Bingisser R, et al. Midregional pro-atrial natriuretic peptide and outcome in patients with acute ischemic stroke. J Am Coll Cardiol. 2010 Sep;56(13):1045–53. doi: https://doi.org/10.1016/j.jacc.2010.02.071
  74. Llombart V, Antolin-Fontes A, Bustamante A, Giralt D, Rost NS, Furie K, et al. B-type natriuretic peptides help in cardioembolic stroke diagnosis: pooled data meta-analysis. Stroke. 2015 May;46(5):1187–95. doi: https://doi.org/10.1161/STROKEAHA.114.008311
  75. Luchner A, Behrens G, Stritzke J, Markus M, Stark K, Peters A, et al. Long-term pattern of brain natriuretic peptide and N-terminal pro brain natriuretic peptide and its determinants in the general population: contribution of age, gender, and cardiac and extra-cardiac factors. Eur J Heart Fail. 2013 Aug;15(8):859–67. doi: https://doi.org/10.1093/eurjhf/hft048
  76. Kishore AK, Hossain MJ, Cameron A, Dawson J, Vail A, Smith CJ. Use of risk scores for predicting new atrial fibrillation after ischemic stroke or transient ischemic attack-A systematic review. Int J Stroke. 2022 Jul;17(6):608–17. doi: https://doi.org/10.1177/17474930211045880
  77. Kleindorfer DO, Towfighi A, Chaturvedi S, Cockroft KM, Gutierrez J, Lombardi-Hill D, et al. Guideline for the prevention of stroke in patients with stroke and transient ischemic attack; A guideline from the American Heart Association/American Stroke Association. Stroke. 2021 Jul;52(7):e364–467. doi: https://doi.org/10.1161/STR.0000000000000375
  78. Schlaganfall-gesellschaft Ö. Positionspapier - Update 2018 Detektion von Vorhofflimmern beim kryptogenen Hirninfarkt. 2018. p. 1–16. Available from: https://www.ögsf.at/wp-content/uploads/2016/11/Positionspapier-2018_OEGSF_neurologisch.pdf
  79. Rubiera M, Aires A, Antonenko K, Lémeret S, Nolte CH, Putaala J, et al. European Stroke Organisation (ESO) guideline on screening for subclinical atrial fibrillation after stroke or transient ischaemic attack of undetermined origin. Eur Stroke J. 2022 Sep;7(3):VI. doi: https://doi.org/10.1177/23969873221099478
  80. Häusler KG, Gröschel K, Köhrmann M, Schnabel RB, Anker SD, Brachmann J, et al. Position Paper on Atrial Fibrillation Detection after Ischemic Stroke: Working Group Heart and Brain of the German Cardiac Society (DGK) and the German Stroke Society (DSG). Aktuelle Neurol. 2018;45(2):93–106. Available from: https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-118476.pdf
  81. Tuna MA, Rothwell PM; Oxford Vascular Study. Diagnosis of non-consensus transient ischaemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis. Lancet. 2021 Mar;397(10277):902–12. doi: https://doi.org/10.1016/S0140-6736(20)31961-9
  82. Kirchhof P, Camm AJ, Goette A, Brandes A, Eckardt L, Elvan A, et al.; EAST-AFNET 4 Trial Investigators. Early Rhythm-Control Therapy in Patients with Atrial Fibrillation. N Engl J Med. 2020 Oct;383(14):1305–16. doi: https://doi.org/10.1056/NEJMoa2019422
  83. Jensen M, Suling A, Metzner A, Schnabel RB, Borof K, Goette A, et al. Early rhythm-control therapy for atrial fibrillation in patients with a history of stroke: a subgroup analysis of the EAST-AFNET 4 trial. Lancet Neurol. 2023 Jan;22(1):45–54. doi: https://doi.org/10.1016/S1474-4422(22)00436-7
  84. Park J, Shim J, Lee JM, Park JK, Heo J, Chang Y, et al.; RAFAS Investigators*. Risks and Benefits of Early Rhythm Control in Patients With Acute Strokes and Atrial Fibrillation: A Multicenter, Prospective, Randomized Study (the RAFAS Trial). J Am Heart Assoc. 2022 Feb;11(3):e023391. doi: https://doi.org/10.1161/JAHA.121.023391
  85. Turc G, Calvet D, Guérin P, Sroussi M, Chatellier G, Mas JL; CLOSE Investigators. Closure, anticoagulation, or antiplatelet therapy for cryptogenic stroke with patent foramen ovale: systematic review of randomized trials, sequential meta-analysis, and new insights from the CLOSE study. J Am Heart Assoc. 2018 Jun;7(12):e008356. doi: https://doi.org/10.1161/JAHA.117.008356
  86. Sposato LA, Chaturvedi S, Hsieh CY, Morillo CA, Kamel H. Atrial Fibrillation Detected After Stroke and Transient Ischemic Attack: A Novel Clinical Concept Challenging Current Views. Stroke. 2022 Mar;53(3):e94–103. doi: https://doi.org/10.1161/STROKEAHA.121.034777
  87. Fridman S, Jimenez-Ruiz A, Vargas-Gonzalez JC, Sposato LA. Differences between Atrial Fibrillation Detected before and after Stroke and TIA: A Systematic Review and Meta-Analysis. Cerebrovasc Dis. 2022;51(2):152–7. doi: https://doi.org/10.1159/000520101
  88. Scheitz JF, Erdur H, Haeusler KG, Audebert HJ, Roser M, Laufs U, et al. Insular cortex lesions, cardiac troponin, and detection of previously unknown atrial fibrillation in acute ischemic stroke: insights from the troponin elevation in acute ischemic stroke study. Stroke. 2015 May;46(5):1196–201. doi: https://doi.org/10.1161/STROKEAHA.115.008681