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| www.smw.ch |
| Cottagnoud P. |
Swiss Med Wkly 2008;138:93–99
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| Minireview Peer reviewed article |
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| Summary Daptomycin, a new lipopeptide antibiotic, is highly bactericidal against the majority of Grampositive human pathogens, including methicillinresistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. Its mechanism of action is unique resulting in the destruction of the membrane potential without lysing the cell wall. The mechanism of action of daptomycin, its antibacterial spectrum, the development of resistance and pre- and clinical studies are discussed in this review. |
Department of Internal Medicine, Inselspital Bern, Switzerland |
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Copyright © 2008 EMH Swiss Medical Publishers Ltd. |
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